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Deleterious off-target effects in women 10 years or more past menopause, such as ovarian, endometrial, and breast cancers, intravascular thrombosis, cardiovascular episodes, and stroke, and suppression of endogenous testosterone and libido and increased risk of prostate cancer in men, have precluded broad clinical applications (Hall and Phillips, 2005

Energy levels stabilise as the body adjusts to lower calorie intake

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It directly neutralizes free radicals and reactive oxygen species that can damage cellular components like DNA, proteins, and lipids