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Aging cell, doi: (2019 (in press))

64 In serine proteases, neutrophil elastase (NE), cathepsin G and proteinase-3 destroy lung tissue by degrading ECM components, and induces epithelial cells and endothelial cells to release a variety of inflammatory factors to activate and chemoattract neutrophils to produce lung inflammation

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10.1136/bmj.j1493 BMJ

While this can be beneficial for people with mood disorders, such as depression, it can sometimes do the opposite of what was intended, and lead to restlessness, anxiety, trouble sleeping, and worry