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Data availability statement All papers included in the meta-analysis and systematic review are listed with additional information in Supplementary Material S1, and online with options to filter the database ( Data used for the meta-analysis was derived from papers cited in the reference section and contacting respective authors

Many patients achieve their maximum weight loss between months 6 and 12 of treatment, and levothyroxine adjustments may be needed even after thyroid labs initially normalized at lower doses

Semaglutide is a subcutaneous injectable medication used for clinically supported weight loss

The main difference is the specific GLP-1 receptor agonist they contain

Antiobesity drug therapy can be used in conjunction with a low-calorie diet and increased physical activity to manage weight in adults with a BMI of 30 kg/m 2 or 2730 kg/m 2 with weight-related comorbidity, such as dysglycemia, hypertension, dyslipidemia, or obstructive sleep apnea