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The literature identifies hypoglycemia as the most significant documented risk, driven by IGF-1 LR3s effect on cellular glucose uptake, alongside receptor desensitization with prolonged exposure and contraindications for individuals with a history of malignancy
Butylene glycol and propanediol indicate a demand for effective humectants that enhance moisture retention without causing irritation
As it has been suggested that NOX2 is important for the initial oxidative burst following SE that contributes to seizures in trauma and chemically induced epilepsy models (Zilberter et al., 2022), the efficacy of NOX inhibition in chronic epilepsy and in a clinically relevant window following a seizure inciting event needs further evaluation
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