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Some of the fragments, for which X-ray structures were obtained, were found in the doorstop pocket expected to be critical for TGR inhibition and adjacent to the NADPH binding site (Fig

[DOI] [PubMed] [Google Scholar] 60.Schoenfeld B.J., Contreras B., Krieger J., Grgic J., Delcastillo K., Belliard R., Alto A

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The DAC-modified version binds covalently to albumin in the bloodstream, extending its reported terminal half-life to approximately 68 days, compared with minutes for unmodified GHRH analogues