Additionally, BBR serves as an FXR and TGR5 agonist, pivotal in modulating the metabolic homeostasis of BAs, thereby intervening in liver cirrhosis by mediating the crosstalk between BAs metabolism and gut microbiota (Liu et al., 2022)
However, hormone levels decline as we age, which contributes to decreased energy, muscle loss, and various other age-related changes
Senomorphics An alternative approach of the use of senolytics, which clear senescent cells, is the use of senomorphics to ameliorate their SASP (summarized in: (55))
IGF-I/IGF-IR signaling in chondrogenesis Although the above global KO mice confirmed the importance of IGF-I/IGF-IR signaling in supporting skeletal development, they did not specify the action of IGF-I signaling in specific cell lineages in the bone or exclude the impact of other systemic derangements on the skeleton
Supports Endurance Helps support stamina and prolonged physical performance