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Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice

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While simple fatty liver rarely causes problems, MASH can progress to cirrhosis and liver failure over years or decades

Furthermore, while chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections remain established risk factors for HCC, they also induce changes in lipid and glucose homeostasis

Resumption may be considered later with a modified plan, slower titration, or additional psychiatric supports if benefits outweigh risks