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Research indicates that sustainable weight loss of 5-10% body weight can significantly reduce cardiovascular and metabolic disease risk, regardless of medication use

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If experiencing severe, persistent upper abdominal pain (especially if radiating to the back) with or without vomiting, they should stop taking the medication immediately and seek urgent medical care, as these may be signs of pancreatitis

[25] It provides a more stable, long-term picture of glycemic control, indicating that statistically, the HbA1c number offers more signal and less noise than an instantaneous reading