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The mechanism of action includes several key effects: they stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppress glucagon release (which reduces hepatic glucose production), slow gastric emptying, and act on appetite centres in the brain to promote satiety and reduce food intake

The UK SmPCs for Wegovy (semaglutide 2.4 mg) and Mounjaro (tirzepatide), available via the Electronic Medicines Compendium (EMC), provide detailed information on GI adverse reactions and class-related warnings such as pancreatitis and gallbladder disease

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Misuse at doses above 200mg can trigger hallucinations, confusion, and respiratory depressionabuse potential is particularly high among teenagers seeking psychoactive effects