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Description

Epoxyeicosatrienoic acid analog EET-a blunts development of lupus nephritis in mice

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Unlike topical selftanners that merely stain the outer layer of skin, this agent drives an internal biological response, closer in spirit to what happens after UV exposurejust via a drug-like mechanism rather than sunlight

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Not theoretical concerns

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Patients with newly diagnosed Graves disease showed increased levels of mRNA expression of CAT (3.821.28-fold increase), GPx-1 (2.430.67-fold increase) and SOD-1 (1.800.62-fold increase) compared to euthyroid subjects

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Mean weight loss further increased at 36 weeks for those receiving orforglipron to 9.4% with the 12 mg dose, 12.5% with the 24 mg dose, 13.5% with the 36 mg dose and 14.7% with the 45 mg dose compared with 2.3% with placebo

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