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EJNMMI Res

In particular, risk factors such as obesity (especially visceral adiposity), smoking, high blood pressure, diabetes mellitus, and dyslipidemia contribute significantly to this development

The hallmarks of oxidative stress, including malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OHdG), are often elevated in chronic pain animal models, highlighting the pathophysiological significance of oxidative damage [26]