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The 2004 Wilding paper in Current Opinion in Investigational Drugs compiled the AOD-9604 metabolic-research framing then in development (PMID 15134286)

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Interestingly, the same study found that, in rats, tirzepatide suppressed lipid intake without affecting sucrose (carbohydrate) consumption in a choice-based assay, implying that the effects of these medications may be macronutrient specific (Geisler et al., 2023)

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