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While direct evidence in humans is limited (for obvious ethical reasons), the mechanism of action is concerning enough to make this one of the most serious GHK-Cu contraindications

The quality and concentration of the preservative directly influence how long the multi-dose vial remains safe to use after first puncture

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The anti-aging peptide stack at Balanced might include peptide therapy to restore growth hormone levels to their younger baseline, GHK-Cu for collagen production and skin quality, peptide therapy for systemic inflammation reduction, and mitochondrial peptides like SS-31 or MOTS-c for cellular energy optimization

2012;7:e40156