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To really decipher the role of DPP4 in different tissues and their crosstalk with other target tissues, it is of great importance to study tissue-specific KO models

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Lastly, utilizing RNAScope in situ hybridization in the lower intestines of mice, we observed that GLP-1 cells expressed generic markers of secretory cells such as Snap25 and Nefm , but neither synaptic markers such as Syn1 and Nrxn2 , nor glutamatergic markers such as Slc17a7

[DOI] [PubMed] [Google Scholar] 99.Baggio LL, Drucker DJ

Compared to Western diet, MedDiet promotes reduced overall fat intake, with primary intake of healthy fats like olive oil, resulting in lowered production of secondary BAs, favoring reduced inflammation and a decreased risk of obesity