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VA Cooperative Study Group

Isotopologue ratios from our [U- 13 C]glucose tracing experiments are consistent with SAAR increasing TCA cycle anaplerosis through PC (i.e., the generation of OAA from pyruvate) and the resulting OAA being preferentially directed to asparagine rather than flux through the TCA cycle

When timed with Ipamorelin which triggers GH release through a separate receptor the pulse is significantly larger than either compound produces alone