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This characteristic may improve renal function by increasing renal blood flow, urine flow rate, preventing elevated plasma creatinine, reducing tubular necrosis, increasing renal interstitial fluid and glomerular filtration rate, and cytoprotective and anti-inflammatory effects [12,13], and may improve glomerular hyperosmosis in patients with T2DM in some cases [14]

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Perimenopause, marked by increasing irregularity and lengthening of menstrual cycles, and postmenopause, which begins 12 months after the last menstrual period