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Animal Model:NMRI-Hannover (male, 30 g, deep partial skin thickness burns induced by 5 s direct flame exposure covering 20% total body area) [2] Dosage:i.p.: 10 ng/kg, 10 g/kg

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The illness is characterized by gradual loss of dopaminergic neurons in the substantia nigra and the appearance of Lewy bodies, which include aggregation of alpha-synuclein, extensively dispersed proteins in the cerebral tissues

Addressing these barriers are essential before such systems can be routinely implemented for comprehensive evaluation and translation