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Thyroid Meds and PPIs: Managing the Morning "Traffic Jam" Both thyroid medications and proton pump inhibitors (PPIs, medications that significantly reduce stomach acid production) are taken first thing in the morning, 30 to 60 minutes before your first meal essentially, the same time as a GLP-1 pill

If you have a dedicated medication area, even better

This combination increases hypoglycemia risk, with symptoms including shakiness, sweating, and confusion