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The anionic nature of superoxide and the fact that it is mostly produced in the mitochondrial matrix determine that the bulk of antioxidant defenses to neutralize superoxide and other ROS reside in the matrix

In the nigrostriatal tract system, dopamine undergoes autooxidation or oxidative deamination by monoamine oxidase-B, both of which aggravates with age, leading to increased production of peroxides and hydroxyl radicals 41

The modification level of m 6 A was determined as the percentage of m 6 A out of the total amount of A, to normalize the amount of mRNA injected from different samples

Yu, H., Shao, X., Guo, Z., Pang, M., Chen, S., She, C., et al