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Given the reduced levels of activated HGF and cMet in hepsin / mice, combined with the increased abundance of GJs, we hypothesize that these mice may be more vulnerable to oxidative stress, potentially exacerbating the severity of APAP-induced liver injury

This comes after several prior warnings

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Research reference: safety & tolerability observations In controlled research environments, IGF-1 LR3 has generally been described as well-tolerated