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In vitro experiments showed that 10 ng/mL IGF-1 LR3 could increase the proliferation rate of breast cancer MCF-7 cells by three times, and reduce the sensitivity of chemotherapy drugs (such as paclitaxel) by 40%

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In-vitro studies frequently document additive or synergistic GH output when both are present

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For example, a study designed to investigate the direct gene modulating effects of the peptide sequence itself, independent of copper delivery, might utilize apo-GHK in a copper-depleted culture medium