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Indeed, insulin regulates renal gluconeogenesis by influencing enzyme production or activity associated with the availability of gluconeogenic precursors (Cano, 2001), an influence anticipated to be diminished or impaired in individuals with MetS or obesity-related insulin resistance (Rebelos et al., 2024)

In addition, unbiased studies of combinations of treatment options for supplements, including large cohort clinical trials, will lead to evidence-based medicine

Efstratiadis G, Tsiaousis G, Athyros VG, Karagianni D, Pavlitou-Tsiontsi A, Giannakou-Darda A, Manes C

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