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Enzyme kinetics assays revealed that compound 30 showed mixedtype inhibition when the inhibitor binds preferentially to the free enzyme rather than the enzymesubstrate complex
Nagendra et al
Activation of GLP-1 receptors also results in nonglycemic effects in a variety of tissues, by acting directly on tissues expressing incretin receptors, as well as through indirect mechanisms regulated by endocrine and neuronal pathways
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Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating
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