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If peak concentration drives the worst of the nausea, and split dosing lowers the peak by 20%, then a meaningful reduction in nausea intensity is pharmacologically plausible

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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or References Stoffel M, Espinosa R, Le Beau MM, Bell GI

Treatment with GLP-1 RAs has been associated with improved insulin sensitivity, as reflected by reductions in Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) scores, and these changes often align with improvements in psoriasis severity