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Ideally, the targeted receptor- or carrier-mediated transport processes for brain targeting should occur exclusively at the BBB to avoid off-target delivery

Despite not fully comprehending the mechanisms underlying these disorders in chronic kidney disease (CKD), the robust association among homocysteine, cysteine, S-adenosylmethionine, S-adenosylhomocysteine, and plasma creatinine levels, as well as the glomerular filtration rate (GFR), indicated that these compounds were excreted in the urine

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