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The LEADER and SUSTAIN 6 trials were both time-to-eventdriven (3.8 and 2.1 years, respectively), and both were longer duration than the event-driven PIONEER 6 (1.3 years) trial, which showed no increase in CV risk but no superiority for lower MACE

The timeline for side effects varies on GLP-1 agonists generally, and emotional side effects are no exception