Direct Comparison: Real-World Weight Loss Examples: 250-Pound Person: With Tirzepatide (Mounjaro/Zepbound/Compounded): Average loss: 50-56 pounds Final weight: 194-200 pounds Timeline: 16-20 months With Semaglutide (Wegovy/Ozempic/Compounded): Average loss: 37 pounds Final weight: 213 pounds Timeline: 16-18 months 200-Pound Person: With Tirzepatide: Average loss: 40-45 pounds Final weight: 155-160 pounds Timeline: 16-20 months With Semaglutide: Average loss: 30 pounds Final weight: 170 pounds Timeline: 16-18 months Brand vs Compounded Effectiveness: Common Question: Is compounded as effective as brand-name? Short Answer: Yes, when properly compounded
Today is the Worst GLP1s+ Will Ever Be GLP1s+ More effective (5% to 22% weight loss and on their way to 25%+) More expansive disease management (diabetes, obesity, CVD, CKD, OSA, and studied for more) Less frequent (2x per day to 1x week and on their way to 1x/month to 1x/year?) Additional effective options in orals are on their way Insurance Coverage Medicare adding coverage for CVD (hopefully more diseases on the way as labels expand) Medicaid added 5 states in just 2023 Federal government added all employees and family members in 2023 Commercial employer coverage increased by 35% in 2023, with more employers considering it The Treat and Reduce Obesity Act (TROA) has been introduced in Congress to encourage Medicare coverage Costs Zepbound, a more effective drug, launched ~20-30% cheaper than Wegovy, with a savings card that put it at just over 1/3rd of the price at the time
When NNMT runs too high in fat tissue, it wastes a form of vitamin B3 that the body needs to make NAD+
Therefore, the current evidence is more appropriately interpreted as suggesting a possible conception-window benefit after metabolic optimization, rather than confirming a reproducible treatment effect on hard reproductive outcomes (111, 112, 124)
J Neurosci 27:1399714006 Circu ML, Aw TY (2008) Glutathione and apoptosis
