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S4E), altered ubiquitylation at one or more lysine residues was detected on multiple reported USP7 substrates, including UBE2E1, HUWE1, RNF220, NEDD4L, TRIP12, SIRT1, MAP4, MARCKS, and CCDC71L, indicating effective inhibition of USP7 activity by P5091 in iNeurons (Fig

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Stemler, K