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A 2021 review published in Nutrients found that GLP-1 receptor agonist use was associated with reduced dietary intake of multiple micronutrients including B12, particularly in patients following calorie-restricted eating patterns, supporting the rationale for monitoring B12 status during treatment even in patients without pre-existing deficiency risk factors

J Clin Pharmacol

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Detailed experiments to improve the therapeutic and pharmacokinetic properties of selected compounds resulted in designed molecules that inhibit the in vitro electron transfer to flavodoxin physiological partners and also inhibit growth of H

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