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Visceral adipose tissue is itself a primary driver of insulin resistance
Regulation of metabolic pathways by supplementation of structural analogs of metabolites (antimetabolites) inhibiting metabolic reactions is used to search for limiting steps of biosynthesis and ways to overcome them, including development of strain antimetabolite resistance (Schmidt et al., 1996
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The neurological consequences of untreated B12 deficiency can be serious and potentially permanent, including subacute combined degeneration of the spinal cord, which affects both sensory and motor pathways
Liver injury from herbal and dietary supplements
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