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Are there cases where treatment is not recommended

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However, systemic effects from distant-site injection are also documented, and for diffuse neuropathies affecting multiple nerve territories, systemic administration may provide more uniform coverage

Gut microbiota composition (including Firmicutes , Bacteroidetes , Akkermansia , and Bifidobacterium ) influences host metabolism by producing short-chain fatty acids (SCFAs), generating secondary bile acids, modulating immune and inflammatory pathways, and stimulating GLP-1 secretion from intestinal L-cells

60% of the weight comes back within a year of stopping GLP-1s