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On immune cells, inhibition of DPP-4/CD26 results in anti-inflammatory effects via regulation of chemokines and anti-inflammatory cytokines like IL-10 and transforming growth factor (TGF)- (83, 84) and DPP-4 might also impact macrophage polarization

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It can be found also in saliva and urine

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Retrieved 14 May 2022, from A Phase III, randomized, double blind, placebo controlled, parallel group study, to evaluate the safety and efficacy of subcutaneous implants of afamelanotide (16 mg) in patients suffering from polymorphic light eruption (PLE)