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This dual mechanism explains why the compound produces such pronounced effects on adipose tissue lipid content without affecting lean tissue or overall energy intake in research models

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High-dose supplementationparticularly intramuscular injections that can deliver 1,000 micrograms or morecreates substantially elevated serum B12 levels compared to dietary intake, which may more readily trigger these bacterial changes, though comparative studies between different forms are limited

Oral vitamin B 12 versus intramuscular vitamin B 12 for vitamin B 12 deficiency 22 Background: Vitamin B 12 deficiency is common, and the incidence increases with age