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Description

Positively stained MT yielded a reddish brown-colored product in nuclei and cytoplasm of hepatocytes (A) control rat liver, (B) curcumin (400 mg/kg)-treated rat liver, (C) Cd (5 mg/kg)-treated rat liver, (D) curcumin (200 mg/kg) + Cd-treated rat liver, (E) curcumin (400 mg/kg) + Cd-treated rats liver, (F) vitamin C (100 mg/kg) + Cd-treated rat liver, (G) curcumin (200 mg/kg) + vitamin C + Cd-treated rat liver, (H) curcumin (400 mg/kg BW) + vitamin C + Cd-treated rat liver

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The precise regulation of ALS pathogenetic mechanisms is still elusive, despite the abundance of identified mechanisms mediating MN degeneration and death, including neuroinflammation, glutamate excitotoxicity, altered RNA metabolism, mitochondrial dysfunction, impaired cytoskeletal integrity, altered axonal transport dynamics, OS [71, 84, 85]

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