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There are many possible causes of a dark spot on the lip, and treatment will vary based on the underlying cause

As with any medication, side effects are possible but many clients do not experience them

Secondary carnitine deficiency can be caused by increased losses, pharmacological therapy, a number of inherited metabolic disorders [38], poor diet or malabsorption of carnitine, from increased renal tubular loss of free carnitine (Fanconi syndrome), haemodialysis, peritoneal dialysis, or the increased excretion of acylcarnitines[39] with certain drugs

Kanasaki, 2016

This signaling reduces hunger, increases satiety, and decreases food intake