PMID 21903028
Finally, some of these preparations contain particles existing at the nanoscale, which may impart unpredictable biological effects to both the active agent per se and its physical-chemical structure These mechanisms, which may overlap between different formulations, have the potential to alter the bioavailability and downstream kinetics (distribution, metabolism, excretion) of bioactive molecules
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Effect of folic acid, with or without other B vitamins, on cognitive decline: meta-analysis of randomized trials
