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However, under zinc excess, lysosomal destabilization and leakage of cathepsin D into the cytosol can trigger mitochondrial damage and apoptosis via the lysosomemitochondria axis 168

When generated at an improper location, time, or concentration, HOX can potentially damage host tissue

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This binding triggers intracellular cAMP signaling cascades that upregulate GH gene expression and stimulate the exocytosis of stored growth hormone