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74 For instance, in the Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial, weekly semaglutide administration resulted in a mean body weight reduction of 14.9% from baseline among overweight or obese non-diabetic individuals, 76 a magnitude of weight loss previously observed only following bariatric surgery

In: Coccolini, F., Podda, M., Lim, R.B., Chiarugi, M

In one study published in Molecular Nutrition and Food Research, nicotinamide supplementation protected mice against diet-induced obesity, increased energy expenditure, and induced the beiging of white adipose tissue, a process that converts energy-storing fat cells into energy-burning cells

More studies are needed to confirm long-term safety and effectiveness in adolescents

The disavantage often read is that a high dosage may lead to disruptions in the body's natural antioxidant balance or kidney issue