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However, patients taking them alongside other diabetes medications (particularly insulin or sulphonylureas) have an increased risk of hypoglycaemic episodes, which commonly present with fatigue, weakness, and confusion

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This agent exhibited the potential to induce significant body weight reduction alongside improvements in cardiometabolic health parameters, potentially becoming the most potent weight-loss and anti-diabetic therapy in the field of metabolic diseases (Jastreboff et al., 2023)

Pegylated arginine deiminase (ADI-PEG-20), which duplicates arginine and increases tumor stress and cytotoxicity, increased the number of tumor-infiltrating T cells in phase I studies and was safe in combination with anti-PD-1 antibody, but with an increased risk of neutropenia