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proved the oxidative stress implicated by methotrexate and attributed it to augmenting the MDA and MPO, increasing collagen deposition, and reducing GSH

- An AHEI Diet includes a diet rich in fruits, vegetables, whole grains, nuts, legumes, and healthy fats, and LOW in meats, processed foods, sodium, and refined grains (This is compatible with almost all dietary patterns included in the study)

These symptoms require prompt clinical review, especially if there has been a recent dose change, antidepressant adjustment, or major sleep disruption

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