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Structural Modification 3: C18 Fatty Diacid Lipidation The Mechanism of Half-Life Extension The most consequential structural modification in cagrilintide -- and the one that defines it as a "long-acting" analog -- is the attachment of a C18 fatty diacid chain via a structured hydrophilic linker

[DOI] [PubMed] [Google Scholar] 84.Moat S.J., Ashfield-Watt P.A., Powers H.J., Newcombe R.G., McDowell I.F

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