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Rare but serious adverse effects including pancreatitis, gallbladder disease, and acute kidney injury (usually secondary to dehydration from vomiting) remain possible

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Although direct evidence for TSP1 involvement in the stabilization of the lung ECM is lacking, TSP1 binds collagen I 25 , fibrinogen/fibrin, fibronectin 23 , heparan sulfate proteoglycans 24 , laminin 26 , as well as integrins such as 3 1 23 which is highly expressed by alveolar epithelial cells 27

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Patients with pernicious anemia are three times more likely to have gastric carcinoma compared to general population