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Interestingly, many of the hub targets have been reported to be involved in cell proliferation, tumorigenicity, and other biological functions, and we will explore these further in the following discussion section

When these isolated senescence cells were presented with FOXO4-DRI peptide, researchers reported that the peptide appeared to block FOXO4 proteins, allowing p53 to bind with DNA, which led to the nuclear exclusion of p53 and induction of apoptosis of the senescent Leydig cells