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GLP-1 receptor agonists (semaglutide, tirzepatide) are peptide drugs cleared by proteolytic cleavage, not by hepatic CYP450 enzymes, so there is no enzymatic pathway linking the two

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10.1093/humupd/dmm043 [DOI] [PubMed] [Google Scholar] 5.Tamura H, Kawamoto M, Sato S, Tamura I, Maekawa R, Taketani T, Aasada H, Takaki E, Nakai A, Reiter RJ, Sugino N

In vivo OVA-induced allergic rhinitis models treated with apigenin demonstrated reduced sIgE, IgG1, IgG2A, -hexosaminidase, histamine, and ECP levels in mouse serum [142]

It works at the cellular level to increase follicle size, stimulate dermal papilla cells, and prolong the anagen phase for thicker, healthier hair growth