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In Wister albino rats weighing approximately 200 g, 600 mg/kg of APAP administration significantly increased ALT, AST, cholesterol, and low-density lipoprotein, which were attenuated to near normal ranges when administrated 50 and 75 mg/kg of Prosopis farcta (Banks & Sol.) J.F.Macbr

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However, using variants that do not dimerize, it has been recently described that homodimer formation of GCL is not required for enzyme activation (Yang et al., 2019)