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I definitely think GLP-1 agonists have a significant role to play in diabetes management and overall agree with the ADA guidelines given the alternatives that cause hypoglycemia and weight gain, but I tend to feel a little more conservative about the weight management role of these medications

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Another meta-analysis, published in 2021, examined the results of six SGLT2 inhibitor trials that included nearly 47,000 subjects with type 2 diabetes, about 31,000 of whom had atherosclerotic cardiovascular disease

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