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Most evidence is derived from small trials, cell culture studies, and animal models rather than large randomized controlled trials

Vitamin B12 is an essential nutrient that helps in energy production, red blood cell synthesis, and the regulation of the nervous system

Sirtuins are known to influence the body's response to oxidative stress and inflammation, and their dysregulation could lead to increased oxidative damage and reduced ATP production (Sara et al., 2021), further exacerbating symptoms of fatigue and metabolic dysfunction

ZNF143 transcription factor mediates cell survival through upregulation of the GPX1 activity in the mitochondrial respiratory dysfunction

Toxicol Lett 224(3):341348 Bobek S, Kahl S, Ewy Z (1976) Effect of long-term fluoride administration on thyroid hormones level blood in rats