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This dose, however, comes with serious side effects including anxiety, irritability, palpitations, acne, rash, sore muscles, achy joints, insomnia, nausea, headaches, and migraines

Notably, many of these non-motor symptoms appear years or even decades before the beginning of overt motor indications, indicating the possibility of serving as early prodromal biomarkers and mirroring the systemic, multisystemic aspect of PD pathogenesis [4]

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