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The increase in circulating homocysteine related to impaired homocysteine metabolism may favor the accretion of a pro-oxidant environment by increasing concentrations of free radicals, by maintaining metal ions in their reduced state suitable for the Fenton reaction, and by changing the redox status of intra- and extracellular thiol groups and, hence, the intracellular redox potential (Mansoor et al, 1993a

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While a high-fat diet increases cholesterol secretion into the bile, which can lead to sludge and stone formation, 9 rapid weight loss and less frequent, low-fat meals also contribute to sludge and stone formation, as discussed later

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