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This distinction matters because peptide research literature groups these three under related but non-identical categories

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18,24 Special Considerations The American Academy of Neurology Practice Parameter on dementia lists vitamin B 12 deficiency as a common comorbidity in older persons and recommends routine assessment of vitamin B 12 levels in older patients with dementia

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ERRs are members of the nuclear receptor superfamily of ligand-activated transcription factors, though unlike most nuclear receptors, ERRs are constitutively active and were long thought to be "orphan" receptors lacking endogenous ligands